A group of researchers explored the possible link between PTSD in young individuals and their risk for developing Alzheimer's disease later in life. Through screening of animal models, these researchers identified the Formin 2 (Fmn2) gene as the link.
The results of the study are quoted below:
- Loss of FMN2 leads to impaired fear extinction in young mice.
- Loss of FMN2 leads to accelerated age‐associated memory impairment.
- Loss of FMN2 accelerates age‐ and amyloid‐induced deregulation of gene expression.
- Vorinostat rescues memory impairment in aged Fmn2−/− and Fmn2−/−_APP mice.
The researchers suggest that their data indicate the possibility to help PTSD patients and reduce risk of developing Alzheimer's disease.